Alli possesses a goal threat that Loftus-Cheek lacks and, crucially, England need if they are to take the burden away from their free-scoring captain.
It is understood that England want to look at Rashford up front alongside Kane, and Loftus-Cheek in midfield with Lingard and Henderson.
Ruben Loftus-Cheek has just four caps to his name and is not alone in having no previous major tournament experience in Southgate's 23-man squad.
England manager Gareth Southgate felt Ruben Loftus-Cheek had shown the level required for international football after he produced a promising debut performance in a 0-0 draw with Germany.
Ruben Loftus-Cheek made his first team debut in the UEFA Champions League against Sporting Lisbon in December 2014.