Having knocked France out of the 2014 World Cup, Mats Hummels inadvertently settled one of the standout games of the first round with an own goal against the world champions.
Hummels put through his own net in the first half to give France a 1-0 win at the Allianz Arena to start their Group F campaign.
Hummels was attempting to stop Lucas Hernández's cross from reaching France forward Kylian Mbappé when he diverted the ball into his own net with his shin in the 20th minute.
Germany won the last of their three European Championship titles back in 1996 and are struggling for form heading into the Euro 2020 finals, which starts Thursday.
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Dortmund is in fifth place in the Bundesliga and would miss out on Champions League qualification for next season unless it can win this season's competition.
Germany qualified for Russia with a perfect record of 10 wins, but Hummels said the last time the team played well was when they wrapped up qualification late last year.
Hummels is back in training after a neck injury kept him out of the win against Sweden and is expected to face the South Koreans.
Germany start their campaign against Mexico in Moscow having won just one of their six friendlies since qualifying for Russia 2018
Bayern Munich are second in the Bundesliga behind Borussia Dortmund after flooring Freiburg 5-0 last Saturday in Heynckes.