PSG moved three points clear of second-place Lille, which can move level on points by winning at fifth-place Rennes on Sunday but has a vastly inferior goal difference.
The 48-year-old Argentine will "respect isolation and is subject to the appropriate health protocols", PSG said on Twitter.
Pochettino's first home game as coach comes on Saturday when PSG take on Brest following their 1-1 draw with Saint-Etienne in midweek.
PSG announced on its website that former Tottenham manager Pochettino had signed a contract until June 30, 2022 with an option for an additional year.
The 47-year-old German arrived at the Parc des Princes on a two-year contract in 2018, and guided the Parisians to their first-ever Champions League final last season.
Pochettino was a fan favourite at Spurs as he assembled one of the most exciting young teams in the Premier League.
The Argentine winger was preferred to fit-again playmaker Christian Eriksen by manager Mauricio Pochettino
Spurs moved back up to fifth in the Premier League, still six points adrift of leaders Liverpool.
Tottenham striker Kane scored his 35th goal of the season two minutes from time to beat Crystal Palace 1-0 on Sunday.
Combined with Chelsea’s defeat at Manchester United, the win moved his side back into the top four despite a less than convincing performance.
Tottenham make the short journey across London to take on Crystal Palace with manager Pochettino comparing midfielder Dembele to Maradona.
Tottenham forward Kane had seen his first penalty saved by Loris Karius five minutes from time with the score at 1-1.
Kane and Alli were each shown yellow cards for studs-up lunges on City forwards Raheem Sterling and Kevin de Bruyne.
The gaffer said one start to lose when they start to think negative, and his side is going to enjoy the against Manchester City as it's a fantastic challenge.
England's Football Association is investigating reports of a mass brawl that erupted in a corridor leading away from the Old Trafford tunnel.