Nepal defender Ananta Tamang, who joined SC East Bengal in the January transfer window to fill the Asian quota left empty by Tomislav Mrcela, could be seen in action on Saturday.
Odisha FC's 6-5 win over SC East Bengal in the closing stages of 2020-21 is the highest-scoring match in the tournament history.
Under Diaz, East Bengal have suffered four defeats and four draws to remain at the bottom of the ISL table with worst goal difference (minus 8) among the 11 teams
While two-time champion Chennaiyin appear to be gaining in confidence, the East Bengal side has only one point to show from the three matches they played so far.
Odisha FC will hope to continue their winning run while SC East Bengal and will focus on bouncing back after a defeat to arch-rivals ATK Mohun Bagan.
Croatian defender Franjo Prce (17th) scored a delightful opener for the Red and Golds while Peter Hartley (45+3) equalised at the stroke of half time for the Men of Steel.
SC East Bengal will take on Jamshedpur FC on November 21 to begin their campaign.
The clubs have sought exemption from the AIFF in order to take part in the cash-rich event starting on November 19.