The former India U-19 captain after a disastrous Adelaide Test was benched for the next three and then dropped from the national team for the England series.
The right-hander struck two fours and a maximum, in the 8th over, which fetched his side 14 runs. The duo then changed gears, as UP reached 68 for no loss after 16 overs.
It is not yet known whether Shaw would come out to bat or not in the Mumbai innings.
These batsmen have played an important role in their team's dominant show so far, and they will be keen to get their A game going once again.
Shaw, who will be leading Mumbai, has been on a record-breaking spree.
UP will now meet Gujarat in the first semi-final while heavyweights Mumbai will be pitted against Karnataka in the other last-four clash.
Shaw smashed his third hundred in the tournament after slamming 105 not out against Delhi and 227 not out against Puducherry in the league stage.
The match could boil down to the contest between Kerala's bowlers and Padikkal and Samarth.
Shardul Thakur put on a batting master-class to smash 92 runs off 57 balls in the ongoing Vijay Hazare Trophy against Himachal.
Meanwhile in Indore, Tamil Nadu made short work of Vidarbha after bundling them out for 150 and then chasing down the target in 11.2 overs.
Padikkal smacked nine sixes and as many boundaries in his 145 not out from 125 balls as the opening duo raced to the 285-run target win with 57 balls.
In other matches, Punjab chased down a target of 291 against Vidarbha for a four-wicket win, while Madhya Pradesh handed Andhra a 98-run defeat.
Vijay Hazare Trophy: Devdutt Padikkal scores second successive ton as Karnataka thrash Kerala by nine wickets
Chasing Kerala's 278, Karnataka cantered home with 27 balls to spare with the Royal Challengers Bangalore opener hitting 13 fours and two sixes in an unbeaten knock of 126 from 138 balls.
The ongoing Vijay Hazare Trophy has witnessed compelling action as Mumbai had registered the highest score in the history of the tournament on Thursday
Prithvi Shaw slams 227 not out, highest individual score in Vijay Hazare as Mumbai post 457/4 vs Puducherry
The 21-year-old Prithvi Shaw broke the earlier record of the highest individual score held by Sanju Samson.