Two Egyptian soldiers were killed and two others injured in an attack by militants on their vehicle on the Cairo-Ismailia road, Xinhua reported Friday citing state-run al-Ahram Online.
The attack was carried out by unidentified militants who drove a car with no licence plate.
Military police have arrived at the scene and are combing the area in search of the attackers who have escaped into the desert.
A military helicopter is aiding in the search.
A policeman was killed Sep 24 and two others injured in a similar attack.
Since the Aug 14 dispersal operation against two sit-ins that supported ex-president Mohamed Morsi, security forces have been attacked in several areas across the country.
Many police stations and checkpoints have been attacked and dozens of security personnel killed.