NEW YORK: Scientists have developed a new medical patch with microneedles that can burn off pockets of unwanted fat such as "love handles" and treat metabolic disorders like obesity and diabetes. The patch turns energy-storing white fat into energy- burning brown fat locally while raising the body's overall metabolism, according to researchers at Columbia University Medical Center (CUMC) and the University of North Carolina in the US.
Humans have two types of fat. White fat stores excess energy in large triglyceride droplets. Brown fat has smaller droplets and a high number of mitochondria that burn fat to produce heat. For years, researchers have been searching for therapies that can transform an adult's white fat into brown fat as a treatment for obesity and diabetes. "There are several clinically available drugs that promote browning, but all must be given as pills or injections," said Li Qiang, assistant professor at CUMC. "This exposes the whole body to the drugs, which can lead to side effects such as stomach upset, weight gain, and bone fractures," said Qiang. "Our skin patch appears to alleviate these complications by delivering most drugs directly to fat tissue," he said. To apply the treatment, the drugs are first encased in nanoparticles, each roughly 250 nanometers (nm) in diameter.
The nanoparticles are then loaded into a centimeter- square skin patch containing dozens of microscopic needles. When applied to skin, the needles painlessly pierce the skin and gradually release the drug from nanoparticles into underlying tissue. "The nanoparticles were designed to effectively hold the drug and then gradually collapse, releasing it into nearby tissue in a sustained way instead of spreading the drug throughout the body quickly," said Zhen Gu, associate professor at North Carolina State University in the US. The new treatment approach was tested in obese mice by loading the nanoparticles with one of two compounds known to promote browning in mice: rosiglitazone (Avandia) or beta- adrenergic receptor agonist (CL 316243). Each mouse was given two patches - one loaded with drug- containing nanoparticles and another without drug - that were placed on either side of the lower abdomen.
New patches were applied every three days for a total of four weeks. Control mice were also given two empty patches. Mice treated with either of the two drugs had a 20 per cent reduction in fat on the treated side compared to the untreated side. They also had significantly lower fasting blood glucose levels than untreated mice. Tests in normal, lean mice revealed that treatment with either of the two drugs increased the animals' oxygen consumption - a measure of overall metabolic activity - by about 20 per cent compared to untreated controls. Genetic analyses revealed that the treated side contained more genes associated with brown fat than on the untreated side, suggesting that the observed metabolic changes and fat reduction were due to an increase in browning in the treated mice.