WASHINGTON: Patients may score slightly lower on certain memory tests after undergoing surgery, a study suggests.
The study published in the journal Anaesthesia involved 312 participants who had surgery and 652 participants who had not (with an average age in the 50s).
Surgery between tests was associated with a decline in immediate memory by one point out of a possible maximum test score of 30 points, researchers said.
Memory became abnormal in 77 out of 670 participants with initially normal memory comprising 18 per cent of those who had had surgery compared with 10 per cent of those who had not, they said.
"The cognitive changes we report are highly statistically significant in view of the internal normative standards we employ, and the large sample size of the control, or non-surgery, population," said Kirk Hogan from the University of Wisconsin-Madison in the US.
"However, the cognitive changes after surgery are small - most probably asymptomatic and beneath a person's awareness," said Hogan.
No differences in other measures of memory and executive function were observed between participants having and not having surgery.
Reduced immediate memory scores at the second visit were significantly associated with the number of operations in the preceding nine years.
Working memory decline was associated with longer cumulative operations, researchers said.
"The results await confirmation both in follow-up investigations in our own population sample after more surgeries in aging participants, and by other investigators with other population samples," said Hogan.
He noted that it is too early to recommend any changes in clinical practice regarding prevention, diagnosis, management, and prognosis of cognitive changes after surgery.