Guardiola's side are one point clear of Liverpool as they exacted a measure of revenge after their Champions League quarter-final exit against Tottenham.
Liverpool's clash with Newcastle was due to be played on May 5 whilst Spurs were slated to play Bournemouth on May 6.
City remain on course for a first-ever treble of domestic trophies in England as they survived a nervy finale.
Manchester United face three crucial league games that will have a huge say on whether they finish in the top four.
There have been growing concerns over how football should tackle racism following a number of incidents of abuse both at grounds and on social media.
City have five games left compared to just four for Liverpool, leaving the destiny of the title in the hands of the champions.
The England international's brace and a late goal by Gabriel Jesus sent defending champions City back to the top
The English champions move a point ahead of Liverpool with five games remaining for both sides.
This follows days after a video captured Chelsea fans singing an Islamophobic song about Liverpool's Egyptian forward Mohamed Salah
United were gifted a first-half lead when Robert Snodgrass's clumsy challenge brought down Juan Mata and Pogba sent his first spot-kick down the middle of the goal.
Kane suffered a "significant lateral ligament" injury in the 1-0 first-leg victory over Manchester City on Tuesday.
Rafael Benitez's side moved 10 points clear of the relegation zone thanks to Perez's first half header at the King Power Stadium.
Chelsea stirs some extremely unpleasant memories for everyone connected with the Premier League leaders.
Chelsea, Tottenham and Arsenal are all vying with United for the two places left on offer in the top four
Despite the problems, Sokratis said he did not feel the club's poor away form was becoming a mental hurdle