- Tag results for Harry Kane
Arsenal have lost three of their past six Premier League matches to fall six points behind Chelsea in the race for a top-four finish.
Kane sustained the injury to his left ankle in the closing moments of the 1-0 loss at Wembley and scans have now confirmed the extent of the problem.
Kane was hurt after clashing with United defender Phil Jones in the closing seconds of the match as the visitors dug deep to protect their 1-0 lead at Wembley on Sunday.
Rashford looks reborn under interim coach Solskjaer, scoring three times in the centre-forward position as United have rattled off four straight league wins since Mourinho's sacking.
After decades of disappointment at major tournaments, England's soccer team matched its best overseas World Cup performance earlier this year.
It gave Tottenham a glimmer of hope of a top-two finish in Group B with matches still to come at home to Inter Milan and away to already-qualified Barcelona.
A throwaway comment by Guardiola last year seemed to cause Pochettino offence with what he saw as the suggestion that Spurs are a “one-man” team.
Luis Enrique Spain's can secure top spot in Group 4 with a win, having already beaten England 2-1 at Wembley last month
Harry Kane converted a first-half penalty in typically cool fashion to take him level with Jermain Defoe on 143 goals for the club.
Spurs moved back up to fifth in the Premier League, still six points adrift of leaders Liverpool.
Kane, who won the Golden Boot at this year's World Cup with six goals, has started 61 matches in all competitions for club and country since the start of last season.
Just four months ago, Tottenham striker Kane and Liverpool forward Salah were being hailed as Europe's most feared marksmen after the pair tore through Premier League defences.
Coach Southgate could make up to nine changes from the team that started England's Nations League campaign with a 2-1 defeat by Spain at Wembley Stadium on Saturday.
Kane raged at Dutch referee Danny Makkelie for ruling out a late equaliser as Spain punctured England's post World Cup euphoria by winning 2-1 at Wembley to hand coach Luis Enrique a winning start.
Harry Kane opened the scoring early in the second half at Old Trafford before a double from Lucas Moura sealed the win.