- Tag results for Harry Kane
It gave Tottenham a glimmer of hope of a top-two finish in Group B with matches still to come at home to Inter Milan and away to already-qualified Barcelona.
A throwaway comment by Guardiola last year seemed to cause Pochettino offence with what he saw as the suggestion that Spurs are a “one-man” team.
Luis Enrique Spain's can secure top spot in Group 4 with a win, having already beaten England 2-1 at Wembley last month
Harry Kane converted a first-half penalty in typically cool fashion to take him level with Jermain Defoe on 143 goals for the club.
Spurs moved back up to fifth in the Premier League, still six points adrift of leaders Liverpool.
Kane, who won the Golden Boot at this year's World Cup with six goals, has started 61 matches in all competitions for club and country since the start of last season.
Just four months ago, Tottenham striker Kane and Liverpool forward Salah were being hailed as Europe's most feared marksmen after the pair tore through Premier League defences.
Coach Southgate could make up to nine changes from the team that started England's Nations League campaign with a 2-1 defeat by Spain at Wembley Stadium on Saturday.
Kane raged at Dutch referee Danny Makkelie for ruling out a late equaliser as Spain punctured England's post World Cup euphoria by winning 2-1 at Wembley to hand coach Luis Enrique a winning start.
Harry Kane opened the scoring early in the second half at Old Trafford before a double from Lucas Moura sealed the win.
Kane had never scored in August in 14 previous matches until claiming his team's third goal after 77 minutes on an afternoon when the nine Spurs World Cup stars returned to domestic action.
Kane's fiancee Kate Goodland gave birth to Vivienne Jane Kane and the England captain took to Twitter to reveal the news.
After the month-long drama in Russia, Express picks its team of the tournament. It’s a 4-2-3-1, the most preferred formation this time...
Kane is the first England player to win the coveted prize since Gary Lineker 32 years ago.
Kane, who lead the scoring for England with six goals, said he regretted not having scored since the round of 16 against Colombia.