Cystic Fibrosis worry for north Indians, finds study

Cystic Fibrosis is an inherited disorder that causes severe damage to the lungs, digestive system and other organs in the body.

Published: 07th November 2020 08:30 AM  |   Last Updated: 07th November 2020 08:30 AM   |  A+A-

Lung disease research centre

For representational purposes

By Express News Service

NEW DELHI: Cystic Fibrosis, which was considered to be rare among Indians, is now found in high prevalence — especially among North Indians, found a pilot study on genetic research conducted by the Institute of Medical Genetics and Genomics (IMGG) of Delhi’s Sir Ganga Ram Hospital. 

Cystic Fibrosis is an inherited disorder that causes severe damage to the lungs, digestive system and other organs in the body. The study, published in the BMC Medical Genetics in London, found that for the first time, a high carrier frequency of 4.5 per cent, which was 9 per 200, for Cystic Fibrosis (CF) has been revealed. The carrier frequency of 9 per 200 found in the study has an expected disease prevalence rate of 1:2000.

The study also showed a high carrier frequency for genetic forms of deafness and Pompe disease, among a cohort of 200 subjects from north India. Carrier status does not mean disease. If both husband and wife are carriers then there is a 25 per cent chance of their children suffering from the disease. Based on this carrier rate, the prevalence of CF disease would be as high as one in 2,000 newborns.

“Based on this study, Cystic Fibrosis should be added to beta-thalassemia and spinal muscular disorders that should be screened in all pregnant women to prevent these diseases. It should also be added to the list of disorders for which newborn screening is being done. Sir Ganga Ram Hospital is planning to add CF to the existing newborn screening programme,” said I C Verma, consultant and Advisor at the IMGG. 


Disclaimer : We respect your thoughts and views! But we need to be judicious while moderating your comments. All the comments will be moderated by the editorial. Abstain from posting comments that are obscene, defamatory or inflammatory, and do not indulge in personal attacks. Try to avoid outside hyperlinks inside the comment. Help us delete comments that do not follow these guidelines.

The views expressed in comments published on are those of the comment writers alone. They do not represent the views or opinions of or its staff, nor do they represent the views or opinions of The New Indian Express Group, or any entity of, or affiliated with, The New Indian Express Group. reserves the right to take any or all comments down at any time.

flipboard facebook twitter whatsapp