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Djokovic's exit comes a day after the shock elimination of world number one and red-hot title favourite Jannik Sinner.

Here is a look at some of the favorites still in contention for the title.

The top-ranked Sinner struggled with dizziness and was beaten by 56th-ranked Juan Manuel Cerundolo 3-6, 2-6, 7-5, 6-1, 6-1 after wasting two chances to serve for the match.

The 23rd-ranked Spaniard said Puerta did not inform the rest of the coaching staff before flying to Miami.

When it was finally over after 3 hours and 44 minutes, Djokovic first nearly stumbled to the clay.

She will now meet either fellow former French Open champion Jelena Ostapenko or compatriot Magda Linette.