Barcelona’s first defeat in 10 rounds means it will lose the league lead if Real Madrid takes a point or more at Valladolid on Sunday. Barcelona leads Madrid on goal difference.
As the decade comes to an end, we've picked an XI that would give any other team a run for their money.
Real Madrid, who drew 0-0 at Camp Nou in the midweek Clasico, can draw level top on 39 points but behind on goal difference if they win at home to Atletico Bilbao on Sunday.
Barcelona know their opponents now possess a player who may not be able to rival Messi but, like him, could win this match on his own.
Messi is yet to win a World Cup for his nation after four failed attempts.
Barcelona are already through to the knockout rounds after six-time Ballon d'Or winner Messi scored in a convincing 3-1 victory over Borussia Dortmund last time out.
Messi now has 12 goals this season, the highest in the division and one ahead of Real Madrid's Karim Benzema.
Messi now has 35 hat-tricks in the tournament, while Ronaldo had 34. He registered the goals in the 17th, 41st and 83rd minute of the match.
The 32-year-old further admitted that he had voted for the Senegalese in The Best poll.
But, the US winger was clear about the respect she has for the legends as she went on to add that nobody can knock them off from history - no matter what.
The Socceroos, one of two guest teams invited to the South American football championship, will also face Paraguay, Bolivia, Uruguay and Chile in Group A.
On Monday, Messi won his sixth Ballon d'Or and went ahead of Ronaldo, who has won the award five times.
Diouf tells irate Senegalese fans to cool it after Lionel Messi beats Sadio Mane in Ballon d'Or voting
Mane, who won the Champions League, finished behind Argentine winner Lionel Messi of Barcelona, Dutch team-mate Virgil van Dijk and Portuguese star Cristiano Ronaldo.
The Dutch captain came second to the Argentina forward despite playing a huge role as Liverpool won the Champions League last season, overcoming Messi's Barcelona in the semi-final.
This was Messi's first Ballon d'Or since 2015 and comes after he scored 54 times for club and country in 2018-19, in which FC Barcelona won La Liga, reports BBC Sport.