Veteran opener Dave Warner will be joined by allrounders Mitchell Marsh and Marcus Stoinis as well as fast bowler Mitchell Starc in the 16-man squad after missing the three-match T20 series in India.
Bhuvneshwar Kumar was brought back into the playing XI. in this match.
Rahul, who underwent a hernia operation in Germany recently, was rested for the ODI series against the West Indies starting Friday at Port of Spain.
The Indian pace attack led by Bhuvneshwar Kumar and Jasprit Bumrah feasted on English batters and delivered tight bowling performances to help the visitors clinch the T20 series.
Indians moved on from their slightly-off batting performance in the first half to bundle out hosts for 121 and capture the series.
Skipper Rohit Sharma, who missed the fifth Test in Birmingham after contracting COVID-19, will be travelling to the port city on Wednesday and is expected to feature in the series-opener.
Yuzvendra Chahal had entered India's five-match T20I series against South Africa on the back of a stupendous IPL 2022.
Afghanistan won the final Twenty20 against Zimbabwe by 35 runs to complete a clean sweep of all six limited-overs games on its tour.
The hosts came into the series on a 12-match winning streak but South Africa took the wind out of India's sails with two emphatic victories.
South Africa batter Heinrich Klaasen hopes his match-winning effort against India in the second T20 helps him prolong his international career.
Zaheer Khan said that the Indian team is lacking their trademark fighting spirit in the match and letting their guard down when conditions are not favourable for them.
'Axar Patel sent ahead of Dinesh Karthik to rotate strike': Shreyas Iyer defends bizarre batting order
Promoted at No 6, Axar Patel scored 10 off 11 balls before being cleaned up by Anrich Nortje, while Karthik slammed an unbeaten 30 from 21 balls.
Afghanistan extended its successful tour of Zimbabwe by clinching their Twenty20 series after a 21-run victory in the second match.
Series against South Africa gives opportunity to show exactly what I've worked hard for: Hardik Pandya
Hardik Pandya elaborated on the routine he followed during his time off from the Indian team. "I'm just proud of the process I followed.
Rishabh Pant rotated the bowlers 'poorly' in first T20I vs South Africa: Ex-Pakistan spinner Danish Kaneria
Danish Kaneria has highlighted the poor captaincy of India wicket-keeper batter Rishabh Pant in the first T20I against South Africa.
Rishabh Pant's stakes have suddenly come down post-IPL and that has coincided with the resurgence of Hardik Pandya.
Rassie van der Dussen smashed 75 off 46 balls while David Miller scored 64 off 31 balls to guide Proteas to a historical run chase.
Asked about how they dealt with Delhi's heat, Temba Bavuma said that the contingent had to cut down on practice ahead of the game to keep their players fit.
Top-knocks by Rassie van der Dussen and David Miller took South Africa to a seven-wicket over India, in the first T20I of the five-match series.
The Indian bowlers cut a sorry figure as South Africa achieved their highest T20 run-chase to end India's 12-match winning streak in the format.