US Southern Command announced the strike with its usual language that the vessel was “engaged in narco-trafficking operations” and operated by a designated terrorist organisation.
The Trump administration's campaign of blowing up alleged drug-trafficking vessels in Latin American waters has gone on since early September and killed at least 194 people in total.
Legal experts and rights groups suggest the attacks could amount to extrajudicial killings because they have apparently targeted civilians who do not pose an immediate threat to the United States.
Video posted on social media by U.S. Southern Command shows a black, boat-shaped image before what appears to be an explosion, followed by a column of fire rising from the ocean.