Sam Stosur added this doubles title to the one she won in Flushing Meadows in 2005, and the singles title she earned by beating Serena Williams in 2011.
Salisbury will be playing in the Mixed Doubles Final on Saturday. He is trying to become the first player to win the men's and mixed doubles titles at the U.S. Open since Bob Bryan in 2010.
Naomi Osaka hasn't been beaten in a Grand Slam match since losing to Gauff at the 2020 Australian Open.
Coco Gauff reached the second round of the Western and Southern Open after dispatching veteran Hsieh Su-wei.
Coco Gauff has tested positive for COVID-19, and as a result, she has withdrawn herself from the upcoming Tokyo Olympics.
The 33-year-old German former world number one fell out of love with the game for a spell but is back in the form she showed in 2018.
Gauff will face former Wimbledon champion Angelique Kerber on Monday.
The 17-year-old American produced an assured performance against a former Wimbledon semi-finalist who only returned to the circuit recently after a three year hiatus due to maternity leave.
17-year-old Coco Gauff, Australian Open runner-up Jennifer Brady lead US Olympic tennis team in Tokyo
Notably absent: Serena and Venus Williams, the owners of a combined nine Olympic medals, in addition to their 30 total Grand Slam singles titles and another 14 majors together.