- Tag results for Barcelona
Barca last endured a league defeat at the Camp Nou against Alaves in September 2016 but, following 42 games unbeaten, their run was ended by a brilliant, counter-attacking display from Betis.
The Brazil international will miss the upcoming home La Liga clash against Real Betis at Camp Nou stadium in Barcelona on Sunday.
Lionel Messi once again watched from the sidelines and Barcelona's attack struggled without him as the Spanish side drew 1-1 at Inter Milan in the Champions League.
Messi broke his arm during Barca's win over Sevilla on October 20, with the club predicting he would be out for three weeks.
Suarez came to the rescue of Barcelona on Saturday with a two-goal performance that included a 90th-minute winner to cap a 3-2 comeback at Rayo Vallecano.
Luis Suarez scored a hat-trick to leave Lopetegui's future in serious doubt. After going more than eight hours without a goal earlier this month, Madrid have now managed just one win in six matches.
Without the injured Lionel Messi, Barca ran riot with Philippe Coutinho and Arturo Vidal also scoring, as Ernesto Valverde's men pulled seven points clear of ninth-placed Real in the table.
Two of the world's greatest clubs are engaged in a battle off the pitch just as fierce: the race to one billion euros.
If Florentino Perez's mind is already made up, the result against Barcelona may not matter. A draw, or even a Madrid win, is not beyond the realm of possibility.
Messi scored and then went off injured as Barca beat Sevilla 4-2 at Camp Nou, in a six-goal thriller that never looked like ending in anything other than a home win.
Madrid's slump feels the more entrenched, given they are without a goal in 360 minutes, discounting injury time, and three of their last four matches have ended in defeat.
After consecutive years travelling to the United States for the International Champions Cup, Barca will return to Asia for the first time since playing a friendly in Qatar in December 2016.
Messi has been linked with City several times since former Barcelona boss Pep Guardiola was appointed manager of the Premier League club in 2016.
Barca started the day at the top of the pile and then Atletico Madrid enjoyed a couple of hours at the summit after edging past Real Betis at the Wanda Metropolitano.
The Barcelona number 10 jersey holds significance as football legends Diego Maradona, Ronaldinho and Romario have worn the number 10 jersey of the Spanish football club.