India replaced spinner Kuldeep Yadav with pacer T Natarajan in the playing XI.
Never before has captain Virat Kohli missed Ravindra Jadeja as much as he would have on Friday when Jonny Bairstow and Ben Stokes took the mickey out of India's left-arm wrist and orthodox spinners.
Bairstow had scores of 0, 0, 0 and 28 in the four innings that he played in England's 1-3 Test series defeat against India, prompting Gavaskar to comment that he looked 'uninterested'.
Liam Livingstone replaced Sam Billings in the England playing XI while Dawid Malan came in place of Eoin Morgan.
Batting first, India scored 185 for eight in the 20 overs, with Yadav (57) and Iyer (37) doing the bulk of scoring. In reply, England were stopped at 177 for 8/
Buttler played a sensational knock of 83 from 52 balls to chase down the target of 157 quite comfortably.
There is some change in every game: Gautam Gambhir questions Suryakumar Yadav's omission in 3rd T20I
Suryakumar made way for opener Rohit Sharma, who was rested for the first two games, and the omission of the youngster irked Gambhir.
Buttler in the Powerplay pounced on Shardul Thakur and Yuzvendra Chahal in successive overs and England were never in danger of falling behind the run-rate after that.
Ishan followed it up with a scintillating Vijay Hazare Trophy where he smashed 173 off 94 balls in the very first match.
Former England skipper Vaughan took a dig on the hosts by rating IPL franchise Mumbai Indians as a better T20 side than the Men in Blue.
Kohli was caught by Chris Jordan off Adil Rashid's delivery in the third over and with this, India was reduced to 3/2.
His remark came as England defeated India by eight wickets with 27 balls to spare at the Narendra Modi Stadium in the first T20I of the five-match series on Friday.
England pacer Jofra Archer got 3 wickets while Adil Rashid removed India's captain Virat Kohli.
While left-hander Shikhar Dhawan will open alongside KL Rahul, all-rounder Hardik Pandya will be seen bowling in this five-match series.
India skipper Virat Kohli on Thursday confirmed that Rohit and Rahul are India's first-choice opening pair for the T20I series.