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Director of Public Health Dr T S Selvavinayagam instructed the officials to conduct information, education and communication activities to avoid panic.

The infection, initially seen in rural areas, has spread to Ahmedabad and now affects 13 districts across the state, further worsening the situation.

Concerns rise as fatalities increase; samples sent for further analysis

Three cases from the neighbouring states - two from Rajasthan and one from Madhya Pradesh - have also been treated in Gujarat hospitals, Health Minister Rushikesh Patel said.

It is worth noting that an epidemic of cerebral fever (CHPV) with febrile symptoms was reported in 1965 in the Chandipura district of Maharashtra state.

Of the four children who have died so far, one was from Sabarkantha district and two were from neighbouring Aravalli district.