Senior Congress leader and former minister R Rajagopala Reddy died in the early hours of Wednesday at Sri Venkateswara Institute of Medical Sciences (SVIMS) in Tirupati.
Reddy, who had been suffering from a heart problem since Monday, was admitted to (SVIMS), where he breathed his last around 2 am.
He was 81 and is survived by his wife, two sons and a daughter.
The body has been brought to his native Reddyvaripalle village, where the funeral will be held on Thursday, sources said.
Rajagopala Reddy was elected as MLA five times between 1972 and 1989. He held agriculture and transport portfolios between 1983-85.
Reddy was an expert on water issues of Rayalaseema. He contributed in the construction of Veligallu and Jarikona projects.
Chief Minister N Kiran Kumar Reddy expressed condolences over the death of the former minister.