Four English sides have reached the last eight of Champions League for the first time in a decade with Tottenham striker Kane set to face a host of England teammates who play for Manchester City.
There will be at least one Premier League club in the semi-final as Manchester City and Tottenham will face each other.
Spurs have now taken just one point from their last four Premier League games to see their lead over Manchester United, Arsenal and Chelsea in the fight for a top-four finish diminish.
Third-placed Tottenham are three points above fourth-placed Manchester United and four ahead of fifth-placed Arsenal
Chasing a near-miracle at home to Tottenham on Tuesday, the Germans fell short in their bid to overturn a 3-0 last 16 first leg loss as Harry Kane's winner sealed their 1-0 defeat.
From a clinical performance from Kane to Lloris leading from the front.
This is the first time Tottenham are in the last eight of the Champions League since 2010/11 when they bowed out 5-0 on aggregate to Real Madrid.
Bale has won four Champions League trophies and scored 101 goals in 218 games since joining Real from Tottenham.
Tottenham's hopes of winning the Premier League have been shattered by defeats at Burnley and Chelsea and draw against Arsenal.
Blues boss Maurizio Sarri dropped Kepa for Chelsea's midweek 2-0 win over Tottenham as punishment for the Spaniard's refusal to be substituted during last weekend's League Cup final.